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Environmental DNA reveals temporal variation in mesophotic reefs of the Humboldt upwelling ecosystems of central Chile: Toward a baseline for biodiversity monitoring of unexplored marine habitats

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Environmental DNA reveals temporal variation in mesophotic reefs of the Humboldt upwelling ecosystems of central Chile: Toward a baseline for biodiversity monitoring of unexplored marine habitats

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Technical-legal management standards for digital legislative information services,Estándares técnico-jurídicos de gestión para servicios digitales de información legislativa

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A challenge of rule of Law is to provide access to the contents of legal texts under modern information management standards for its efficient and effective storage, processing, search, retrieval and communication. The article reviews the international standards for digital legislative information services. The author proposes that the legislative semantic web, based on the technologies of structured document (XML), metadata (RDF) and ontologies (OWL) appears as the optimal platform model for the representation, organization and distribution of these legal contents, and is an effective response to the requirements caused by the phenomenon of legislative contamination and the demand for better and easier access to legislation.

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Technical-legal management standards for digital legislative information services,Estándares técnico-jurídicos de gestión para servicios digitales de información legislativa

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Estándares técnico-jurídicos de gestión para servicios digitales de información legislativa

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Energy consumption prediction from usage data for decision support on investments: The EnPROVE approach

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Energy consumption prediction from usage data for decision support on investments: The EnPROVE approach

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Controlled Vocabulary for Resource Type Genres::text::conference object

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Data-Driven Strategies for Achieving School Equity: Insights From Brazil and Policy Recommendations

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Data-Driven Strategies for Achieving School Equity: Insights From Brazil and Policy Recommendations

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Zoledronic Acid Modulation of TRPV1 Channel Currents in Osteoblast Cell Line and Native Rat and Mouse Bone Marrow-Derived Osteoblasts: Cell Proliferation and Mineralization Effect

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Medical and Health sciences::Other medical sciences

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Bisphosphonates (BPs) reduce bone pain and fractures by balancing the osteoblast/osteoclast ratio. The behavior of ion channels in the presence of BPs is not known. To investigate this, the effect of zoledronic acid BP (ZOL) (3 × 10−8 to 5 × 10−4 M) treatment, on ion channels, cell proliferation, and mineralization, has been investigated on preosteoclast-like cells, RAW264.7, preosteoblast-like cells MC3T3-E1, and rat/mouse native bone marrow-derived osteoblasts. In whole-cell patch clamp on cell line- and bone marrow-derived osteoblasts, ZOL potentiated outward currents. On RAW264.7, ZOL (10−4 M)-evoked current was reduced by the Kv channel blocker tetraethylammonium hydrochloride (TEA), but not by the selective TRPV1-channel antagonist capsazepine. On MC3T3-E1 cells and bone marrow-derived osteoblasts, ZOL-evoked current (5 × 10−8 to 10−4 M) was reduced by capsazepine, whereas the selective TRPV1-channel agonist capsaicin potentiated the control current. In the cell proliferation assay, 72 h incubation of RAW264.7 and MC3T3-E1 cells with ZOL reduced proliferation, with IC50 values of 2.62 × 10−7 M and 2.02 × 10−5 M, respectively. Mineralization of MC3T3-E1 cells and bone marrow-derived osteoblasts was observed in the presence of capsaicin and ZOL (5 × 10−8–10−7 M); ZOL effects were antagonized by capsazepine. In summary, the ZOL-induced activation of TRPV1 channel mediates the mineralization of osteoblasts and counterbalances the antiproliferative effects, increasing the IC50. This mechanism is not operative in osteoclasts lacking the TRPV1 channel.

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Zoledronic Acid Modulation of TRPV1 Channel Currents in Osteoblast Cell Line and Native Rat and Mouse Bone Marrow-Derived Osteoblasts: Cell Proliferation and Mineralization Effect

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Opinion Polarization during a Dichotomous Electoral Process

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<jats:p>Political polarization can emerge on electoral campaigns where the population faces a dichotomous decision, with only two voting alternatives. In this paper, we analyze the Twitter conversation around the second round of the 2017 Chilean elections, where voters had to choose between the final two candidates. First, we have estimated the opinions of Twitter users obtaining a distribution of opinions for each day. Next, we have measured the resulting political polarization from the cited opinion distributions and track its evolution during a full week that includes the voting day. We found the conversation to be highly polarized, reaching its maximum during the previous day to the election and significantly decreasing the day after due to the presence of new users who only participated during that day.</jats:p>

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Opinion Polarization during a Dichotomous Electoral Process

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Alignment between United Nations Environmental Assembly Guidance and National Research Priorities

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<jats:p>This study analyzes the alignment between (1) the scientific publications generated within a nation-state, and (2) the United Nations resolutions on climate change research and sustainable development guidelines to which that nation-state is a signatory. Starting with a characterization of Chile’s modern scientific journal output using extensive scientometrics databases, this work contrasts the resulting Chilean analysis with United Nations (UN) resolutions generated at the fifth UN Environment Assembly held in Nairobi in March of 2022. Chile is an interesting choice because the most recent political election installed an environmentally progressive president who has described his administration as the “first ecological government in the history of Chile”. Chile also held a constitutional referendum shortly after the presidential election that would have replaced the existing constitution from 1980 with a more progressive constitution designed to shift the country towards expanded social and environmental rights. The study covers different dimensions and scales, from the interaction of authors, institutions, and disciplines, to the current conditions regarding authors’ gender and the co-author inertia existing in every niche of scientific publication in Chile. The results and recommendations presented in this paper are intended to assist in developing policies for improved scientific–technical knowledge management at the national level.</jats:p>

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Alignment between United Nations Environmental Assembly Guidance and National Research Priorities

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Global Digital Analysis for Science Diplomacy

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<jats:p>Addressing climate change requires innovative, collective action and robust international collaboration. Through joint efforts, nations can significantly reduce greenhouse gas emissions, pioneer sustainable technologies, and implement effective adaptation measures. Science diplomacy and knowledge sharing hold the potential to bolster global stability and peace by directly confronting climate change challenges. Therefore, it becomes imperative to evaluate a country’s alignment of its scientific knowledge system (SKS) with international guidelines. This study delineates the global scientific discourse on climate change and juxtaposes the alignment between an individual nation’s research endeavors and United Nations resolutions concerning climate change and sustainable development. Our methodology integrates data extraction from scientific research databases with advanced textual analysis tools, highlighting this study’s unique focus on the intersection of climate change and UN resolutions. To deliver an empirical analysis, we leveraged complex network theory and advanced text-processing techniques. Our findings demonstrate the trajectory of global scientific output related to these themes, segmented by countries and coupled with CO2 emissions data, key disciplines, and collaboration networks. These insights are instrumental for leaders, policymakers, and stakeholders, highlighting areas of convergence and divergence in national research initiatives essential for achieving global climate goals. Such knowledge is strategically useful for crafting purpose-driven public policies and honoring enduring multilateral pledges to address the climate crisis proactively.</jats:p>

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Global Digital Analysis for Science Diplomacy

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Opinion Polarization during a Dichotomous Electoral Process

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
<jats:p>Political polarization can emerge on electoral campaigns where the population faces a dichotomous decision, with only two voting alternatives. In this paper, we analyze the Twitter conversation around the second round of the 2017 Chilean elections, where voters had to choose between the final two candidates. First, we have estimated the opinions of Twitter users obtaining a distribution of opinions for each day. Next, we have measured the resulting political polarization from the cited opinion distributions and track its evolution during a full week that includes the voting day. We found the conversation to be highly polarized, reaching its maximum during the previous day to the election and significantly decreasing the day after due to the presence of new users who only participated during that day.</jats:p>

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Opinion Polarization during a Dichotomous Electoral Process

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Lorem Ipsum es simplemente el texto de relleno de las imprentas y archivos de texto. Lorem Ipsum ha sido el texto de relleno estándar de las industrias desde el año 1500, cuando un impresor (N. del T. persona que se dedica a la imprenta) desconocido usó una galería de textos y los mezcló de tal manera que logró hacer un libro de textos especimen. No sólo sobrevivió 500 años, sino que tambien ingresó como texto de relleno en documentos electrónicos, quedando esencialmente igual al original. Fue popularizado en los 60s con la creación de las hojas "Letraset", las cuales contenian pasajes de Lorem Ipsum, y más recientemente con software de autoedición, como por ejemplo Aldus PageMaker, el cual incluye versiones de Lorem Ipsum.